创伤后应激障碍中岛叶灰质密度减少:基于象素的磁共振形态学研究
全部作者: | 陈树林 Xia Weiwei 李凌江 Liu Jun He Zhong Zhang Zishu Yan Lirong Zhang Jinli Hu Dewn |
第1作者单位: | 中南大学湘雅2医院精神卫生研究所 |
论文摘要: | 基于象素的形态学(VBM)是1种全脑的、无偏差的描述脑区体积和组织集中对比度的结构磁共振方法。在本研究中,利用VBM研究创伤后应激障碍(PTSD)患者中可能的大脑灰质的异常。12名经历火灾创伤应激的PTSD患者及经历同样应激但无PTSD的正常对照者纳入了本研究,以VBN方法不检测其灰质密度。同对照相比,PTSD患者在以下3个主要的脑区显示有灰质体积的`减少:左侧海马、左侧前扣带皮质和双侧岛叶。本研究为PTSD患者中存在海马和扣带皮质结构的异常提供了证据。同是,本研究也首次为PTSD患者存在岛叶结构的异常提供了证据。 |
关键词: | 灰质密度;形态学研究;双侧岛叶;海马;前扣带皮质 远程下载 论文(免费PDF论文全文) |
发表日期: | 2007年03月29日 |
同行评议: | Insular gray matter density reduction in posttraumatic stress disorder: A voxel-based morphometric study, by Chen et the paper, the authors administered the imaging scans in 12 PTSD sufferers and 12 controls using a method called the voxel-based morphometry (VBM). They found that PTSD sufferers displayed reduced gray matter volumes in the left hippocampus, left anterior cingulate cortex, and (particularly) bilateral insulars when compared to those of controls. The study is interesting, and contributes to the knowledge of PTSD neuroimagings. However, there are several points that the authors have to pay attention to.1. The authors declared that the VBM was a time-saving neuroimaging technique, better than the old methods relating to ROI calculations; and with the old methods, decreased activity in many brain areas including the insular had been reported (page 2, the middle of para 3), then what was the necessity to apply the current protocol? Just because of the time-saving of the VBM? Anyway, the authors need 1-2 pieces of rationale more to conduct the current study.2. In the statistics section, the authors mentioned the use of ANCOVA, but they forgot to present the main effects, degrees of freedom, F values stuff when referring to the analyses of a series of the regional activities in the two groups.3. In the Introduction section, they have mentioned the previous studies that regional changes were found in mPFC of the PTSD sufferers, but they failed to find a reduction in mPFC. Please discuss the discrepancy, since this is interesting (didn’t find the changes with newer techniques?).4. Small points. Please fill-out the proper references in the 3rd para of page 2. Did the authors see that the notes left by a reader (several “Ref?”)? Please also prepare the references (in the text and in the list) in a serious way. Since there are plenty of references are just redundancies, for instances, refs 2 and 36; 47 and 48. Please clear these out. |
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注:同行评议是由特聘的同行专家给出的评审意见,综合评价是综合专家对论文各要素的评议得出的数值,以1至5颗星显示。 |
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