先天性心脏病合并肺动脉高压一氧化氮合酶mRNA表达及临床意义

作者：封加涛，苏艳玲，龚光甫，胡冬煦，曹亚
【关键词】 心脏缺损,先天性；高血压,肺性；一氧化氮合酶；RNA,信使

【Abstract】 AIM: To explore the pathophysiological significance of nitric oxide(NO) and nitric oxide synthase(NOS) in congenital heart defects with pulmonary hypertension. METHODS: Twentyfour patients with congenital heart defects were divided into 3 groups: mild pulmonary hypertension group(n=8), moderate or severe pulmonary hypertension group(n=9), and nonpulmonary hypertension group(n=7). NOS mRNA expression was detected in lung tissues with reverse transcriptase polymerase chain reaction (RTPCR). RESULTS: The NOS mRNA expression levels in the patients with moderate or severe pulmonary hypertension were much lower than those in the ones with mildpulmonary hypertension or nonpulmonary hypertension (P